Salivary biomarkers in rheumatoid arthritis: SOAP-OPERA

Rheumatoid arthritis (RA) is a long-term disease where the body’s immune system mistakenly attacks the joints, causing pain, swelling, and stiffness. It often leads to fatigue and can even affect a person’s mood, sometimes causing depression. Even though treatments have improved, RA still causes serious health problems and can shorten a person’s life if not properly managed. If RA is not kept under control, it can lead to permanent joint damage. It also makes everyday tasks more difficult and can greatly reduce quality of life. The condition often leads to lost productivity and places a financial strain on individuals and society.

Interestingly, gum disease – also known as periodontitis – is one of the most common chronic inflammatory diseases worldwide and may be linked to rheumatoid arthritis. In the UK, it affects nearly half of all adults, with the rate rising to 66% in people over 55. Around 1 in 10 of the population suffers from the severe form of the disease. Gum disease can lead to serious problems like tooth loss if left untreated. Gum disease is another form of long term inflammation in the body, and it might add to the overall burden of RA. However, there is still limited information on how periodontitis might affect health outcomes for people living with RA.

Project aims

We will assess whether people with inflammatory arthritis have gum disease, and test for biomarkers to better understand this connection.