Professor Shishir Shetty

Professor Shishir Shetty co-leads our BRC Inflammatory liver disease theme, and is a Cancer Research UK Advanced Clinician Scientist and Consultant Hepatologist. He leads a laboratory team funded by Cancer Research UK and is a member of the hepatocellular cancer multidisciplinary team at the University Hospitals Birmingham NHS Foundation Trust.

Professor Shetty completed his PhD in Birmingham in 2011, studying the role of the scavenger receptor stabilin-1/CLEVER-1 in lymphocyte recruitment to the liver. He then obtained a Wellcome Trust intermediate fellowship in 2012, and the work during this fellowship confirmed that scavenger receptors like stabilin-1/CLEVER-1 play distinct homeostatic roles in the setting of tissue injury and therefore may be attractive targets for cancer immunotherapy. Scavenger receptors are highly expressed by endothelial cells and macrophages and this has led him to study the contribution of these cell types to the tumour microenvironment. Scavenger receptors are now being trialled as novel immunotherapies for patients with cancer, notably the global multicentre MATINS trial for which Professor Shetty was UK chief investigator.

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