The over-arching strategy of the Trial Design and Delivery theme, led by Professor Philip Newsome, is to focus on early phase clinical trials across the NIHR Biomedical Research Centre with a focus on biological inflammatory pathways. Close working with the research themes will allow for identification and prioritisation of relevant biological pathways in patients with inflammatory conditions. Consistent with this we will prioritise adoption of biological response markers into clinical trial design providing important mechanistic insights into the pathogenesis of inflammatory conditions. This will position us to offer pathway-specific as well as disease-specific early phase trials of anti-inflammatory cellular and re-purposed pharmacological therapies across our areas of clinical interest, offering added value to investigators and SMEs.
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