Inflammatory Sarcopenia

In many chronic inflammatory diseases, including Rheumatoid Arthritis, Inflammatory Bowel Disease and liver disease, loss of muscle mass and strength (sarcopaenia) occurs. Importantly sarcopaenia contributes to poor patient quality of life, reduced ability to cope with challenges such as surgery or infection and higher risk of death. However, the extent of sarcopenia in these patients and the reason behind muscle remains poorly understood, limiting our ability to tackle this insidious wasting condition. The sarcopaenia theme in the BRC, led by Professor Janet Lord who is also director of the MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, will apply research strengths in age-related sarcopaenia to address the issue of loss of muscle mass and strength in Rheumatoid Arthritis, Inflammatory Bowel Disease and liver disease.

It will aim to understand why sarcopaenia occurs and in patients with Rheumatoid Arthritis, Inflammatory Bowel Disease and liver disease and will test interventions known to overcome sarcopaenia in other patient groups or healthy older adults.

The objectives are to determine the extent of loss of muscle mass, quality and strength in Rheumatoid Arthritis, Inflammatory Bowel Disease and liver disease patients; to determine the mechanisms driving sarcopaenia in each of these three conditions; and to test interventions, including drugs, exercise and nutrition, to reverse sarcopaenia in Rheumatoid Arthritis, Inflammatory Bowel Disease and liver disease.

 

FURTHER INFORMATION

 

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close